Cyro-elec. microscopy

Using new preparation techniques, instrumentation and evaluation methods in cryo-electron microscopy (cryo-EM), a detailed description of macromolecules and supra-molecular complexes at medium to high resolution is nowadays possible. Cryo-EM provides substantial contributions to structural biology and is an important technique in integrated structural biology using hybrid approaches that combine X-ray crystallography, NMR-spectroscopy, small angle X-ray (SAXS) and/or neutron scattering (SANS). Cryo-EM is currently not available for structural biology applications at any of the Helmholtz Centres, but a cryo-EM department is planned to be established at FZJ.

Infrastructures: presently none